Can I use SENSE S1 cassettes in the SENSE S2? Mike Stueve September 09, 2023 23:45 Updated No. SENSE S1 cassettes will not work in the SENSE S2. SENSE S1 cassettes will only work in the SENSE S1 device. Related articles Can I use SENSE S2 cassettes in the SENSE S1? How do I know if I have a WaterGuru SENSE S1 or S2 device? WaterGuru SENSE - Replace Cassette How much does the WaterGuru SENSE cost to operate per year? Do I need the mesh bag for my WaterGuru SENSE? Comments 0 comments Article is closed for comments.